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Yep, it's true. Arizona does indeed cheat on Callie in Grey's Anatomy. During a tough time in their relationship, Arizona has an affair with Dr. Lauren Boswell. This ends up causing a lot of emotional turmoil and eventually play a big part in the end of their marriage.

No, Nathan Scott from 'One Tree Hill' isn't unfaithful to Haley James Scott. However, since the seventies, both their relationship and Nathan had been tested. Throughout these trials, though, Nathan remained true to Haley. It has many ups as well as some downs; however, this truth does not change. Their bond grows ever stronger. Let's delve deep into this.

While long-distance strained Derek and Meredith's relationship, causing confusion over his loyalty, the skilled neurosurgeon remained true to his soulmate even when opportunity knocked elsewhere. Mistakes ensued from insufficient connection yet honesty prevailed, clarifying the real story behind his well-meaning move away from Seattle grace and grey-haired love. Readers breathe easier learning misunderstandings not betrayals disrupted the duo though distance built barriers briefly before truth emerged in a satisfying manner, cementing their standing as a fan-favorite, faithful pair through trials.

Nothing doing, Nathan never cheated on Haley in Season 7 of One Tree Hill. He had a couple of scenes with his hot new sports agent, and they led to some confusion -- but the ol' boy stayed loyal to his love. All just some misunderstanding based on a powerful narrative arc. Drama, eh?

In the 'Summer' trilogy by Jenny Han, Jeremiah never cheats on Belly. However, there is a moment of betrayal in 'We'll Always Have Summer', where he confesses to having slept with another girl during a break in their relationship. That really shakes up things but technically it wasn't cheating since they were on a break.

Starlight, also known as Annie January, is the shining star in THE SEVEN, a supergroup that no longer follows any rules. Whether or not Annie cheated on her boyfriend Hughie Campbell has yet to be determined. The two did have their share of quarrels and fusses, mainly arising from the harsh circumstances in their world. Fact remains, however, that their relationship was more than just one between two unique individuals. It was the relationship of a regular human, and a superhuman to boot. Taking this into consideration only makes matters ever trickier: Starlight is living a double life as observer and participant in 'The Seven', with her boyfriend being one of 'The Boys'-a group that is diametrically opposed to her own. Even though things might become so complicated as to appear losing their clarity, it's clear Starlight never cheats on Hughie. Sure there are moments where you might question her commitment. But those doubtings are all either misunderstandings or planned misleadings so that people can get by in this complex socio-political landscape of the world. In the end, it is always clear anew that Starlight places value upon her relationship to Hughie and does not want to lose it through infidelity.

For those sailing in the sea of 'Game of Thrones', it's quite murky and full of surprises. One of which may be the relationship between Daemon and Rhaenyra. While there are discussions about Daemon's loyalty or the lack thereof, the series never explicitly shows him cheating on Rhaenyra.

In 'Grey's Anatomy', Owen Hunt cheated on Cristina Yang with a woman he met at a bar. This event triggers a devastating downfall in their relationship and deeply impacts Cristina. Truly a heartbreaking moment for 'Grey's Anatomy' fans.